Analysis of peritoneal dialysis-related peritonitis pathogenic bacteria and its drug-resistance

Objective: Understand the pathogen spectrum changes of patients with peritoneal dialysis-related peritonitis, and provide a theoretical basis for the prevention of peritonitis, guided by a rational use of medicines in clinical treatment. Methods: Perform a retrospective analysis of the pathogen spectrum, drug sensitivity test results and disease prognosis from 76 cases, admitted to hospital in the past 6 years, of patients with peritoneal dialysis-related peritonitis. Results: Among these 76 cases of peritoneal dialysis-related peritonitis cases, the positive rate is 59.2%, with the highest proportion of gram positive cocci (71.1%), most of which are staphylococcus epidermis (26.7%). Gram positive bacteria have the highest rates of erythromycin resistance (53.1%) and are sensitive to Vancomycin. Gram negative bacteria’s resistance rate of forest reaches 55.6%. Conclusion: Treatment should be based on the results of bacterial culture, with drug sensitivity tests used to select the most sensitive and effective antibiotics. We hereby recommend that empiric therapy in peritonitis can use vancomycin combined with aminoglycoside drugs. Gram negative bacteria and fungus infection peritonitis are the primary causes of patients dropping out of peritoneal dialysis.